Little discussion can be found around the question of whether or not employees of an institution should be permitted to participate as subjects in human research conducted by the institution they work for. To date, there is no specific guidance (protection/provisions) provided by the federal regulations governing research with human subjects. The Office for Human Research Protections (OHRP) presents consideration around students, employees, and normal volunteers in Chapter VI, “Special Classes of Subjects,” of its IRB Guidebook. Similarly, the Centers for Disease Control and Prevention (CDC) offers guidance for employee participation in research. While the enrollment of employees is allowed, there is a potential for fundamental ethical provisions to be compromised. Both the study sponsor and the Institutional Review Boards (IRB) or Independent Ethics Committees (IEC) have a responsibility to address the management of these issues: